| CAS No.: | 110-17-8 |
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| Formula: | C4h4o4 |
| EINECS: | 203-743-0 |
| Nutritional Value: | Nutritional |
| Certification: | ISO, FDA |
| Packaging Material: | Plastic |
| Samples: |
100g 200g 500g 1Kg
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| Customization: |
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Fumaric Acid / Trans-Butenedioic Acid Powder CAS No. 110-17-8 Fumaric Acid
[Product Name]: Fumaric Acid
[Other Name]: Trans-butenedioic Acid
[Apperance]: White fine powder
[Specification]: 99%
[Test Method]: HPLC
[Cas No.]: 110-17-8
[M.F.]: C4H4O
[M.W.]: 116.07
[Solubility]:Soluble in ethanol; partly soluble in water, diethyl ethr, acetic acid; unsoluble in chloroform.
Fumaric acid or trans-butenedioic acid is the chemical compound with the formula HO2CCH=CHCO2H. It is produced in eukaryotic organisms from succinate in complex 2 of
the electron transport chain via the enzyme succinate dehydrogenase. It is one of two isomeric unsaturated dicarboxylic acids, the other being maleic acid. In fumaric acid the carboxylic acid groups are trans (E) and in maleic acid they are cis (Z). Fumaric acid has a fruit-like taste.The salts and esters are known as fumarates. Fumarate can also refer to the C4H2O4−− ion (in solution).
1.Food
Fumaric acid has been used as a food acidulant since 1946. It is approved for use as a food additive in the EU, USA and Australia and New Zealand. As a food additive, it is used as an acidity regulator and can be denoted by the E number E297. It is generally used in beverages and baking powders for which requirements are placed on purity.Fumaric acid is used in the making of wheat tortillas as a food preservative and as the acid in leavening. It is generally used as a substitute for tartaric acid and occasionally in place of citric acid, at a rate of 1 g of fumaric acid to every ~1.5 g of citric acid, in order to add sourness, similarly to the way malic acid is used. As well as being a component of some artificial vinegar flavors, such as "Salt and Vinegar" flavored potato chips, it is also used as a coagulant in stovetop pudding mixes.
2. Medicine
In patients with relapsing-remitting multiple sclerosis, the ester dimethyl fumarate (BG-12, Biogen) significantly reduced relapse and disability progression in a phase 3 trial. It activates the Nrf2 antioxidant response pathway, the primary cellular defense against the cytotoxic effects of oxidative stress.
3.Psoriasis
Various Fumaric acid esters (FAES) have specific immunomodulating (respectively moderate immunosuppression) properties which are responsible for certain effects in the treatment of psoriasis. In the Netherlands, Germany, Austria and the Benelux countries substances derived from fumaric acid have been used for half a century for this purpose.Although it seems that a certain effectiveness exists (and many studies have confirmed the effect), more statistically powerful studies are necessary to provide better evidence of the effectiveness of fumaric acid esters in treatment of psoriasis (e.g. more accurate in terms of the dermatological nosology of this autoimmune disease). Such studies should in the future help specify which psoriasis variants (in terms of the course, the immunological profile of the patient etc.)
are suited to be treated with fumaric acid esters.Fumaric acid is naturally present in the herb called Fumaria officinalis. The top of this herb is used to treat various skin disorders including psoriasis. Baths with this herb have been used for several centuries. At present, these baths (after consultation with a general practitioner or dermatologist) are used as an adjunct therapy to basic treatment.
4. Other uses
Fumaric acid is used in the manufacture of polyester resins and polyhydric alcohols and as a mordant for dyes. Since the early 21st century, it has been used to synthesize one of the first metal-organic frameworks presenting commercial applications thanks to its remarkable adsorption and mechanical properties, combined with a low toxicity compared to other well-studied MOFs.
| Fumaric acid Chemical Properties | |
| Melting point | 298-300 °C (subl.)(lit.) |
| Boiling point | 137.07°C (rough estimate) |
| density | 1.62 |
| vapor pressure | 1.7 mm Hg ( 165 °C) |
| refractive index | 1.5260 (estimate) |
| FEMA | 2488 | FUMARIC ACID |
| Fp | 230 °C |
| storage temp. | Store below +30°C. |
| solubility | 95% ethanol: soluble0.46g/10 mL, clear, colorless |
| form | Fine Crystalline Powder |
| pka | 3.02, 4.38(at 25ºC) |
| color | White |
| PH | 2.1 (4.9g/l, H2O, 20ºC) |
| explosive limit | 0.4 |
| Water Solubility | 0.63 g/100 mL (25 ºC) |
| Merck | 144287 |
| BRN | 605763 |
| Stability: |
Stable at room temperature. Decomposes at around 230 C. Incompatible with strong oxidizing agents, bases, reducing agents. Combustible. |
| CAS DataBase Reference | 110-17-8(CAS DataBase Reference) |
| NIST Chemistry Reference | Fumaric acid(110-17-8) |
| Application | Fumaric acid is an important organic chemical raw material, an intermediate of fine chemical products, and an important derivative of maleic anhydride. It is widely used in the fields of food, paint, resin and plasticizer. |
Spec. Fumaric acid
| Items | Standards |
| Assay(%) | ≥99.0 |
| Mesh | Through 300 Mesh |
| AS PPM | ≤3 |
| Heavy Metals (Pb) | ≤10 |
| Water (%) | ≤0.3 |
| Maleic Acid (%) | ≤0.1 |
| Colour (Pt-Co) | ≤15 Hazen |
| Melting Point(ºC) | 286-289 |
| Solubility (25ºC) | ≥1.00g/100ml Water |
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