API Pharmaceutical Raw Material Docetaxel Powder 99% CAS 114977-28-5

• Powder: Yes
• Customized: Non-Customized
• Certification: GMP, ISO 9001, USP, BP
• Suitable for: Elderly, Adult
• State: Solid
• Purity: >99%
• Model NO.: Pharm002
• Transport Package: as Required
• Specification: 25kg/Drum, DRUM, Aluminum Foil Bag
• Trademark: ALLRIGHT G. C.
• Origin: Shandong
• Production Capacity: 5000 Kilogram/Kilograms Per Month

Product Description

Product:Docetaxel Anhydrous 

CAS No.:114977-28-5

Mol.Formula:C43H53NO14

Appearance: White crystalline powder

Purity(HPLC) : 99%

Docetaxel is a clinically well established anti-mitotic chemotherapy medication used mainly for the treatment of breast, ovarian, and non-small cell lung cancer. Docetaxel has an approved claim for treatment of patients who have locally advanced, or metastatic breast or non small-cell lung cancer who have undergone anthracycline-based chemotherapy and failed to stop cancer progression or relapsed.Administered as a one-hour infusion every three weeks generally over a ten cycle course, docetaxel is considered better than doxorubicin, paclitaxel and fluorouracil as a cytotoxic antimicrotubule agent.

 

1.It is a clinically well established anti-mitotic chemotherapy medication (that is, it  interferes with cell division).

2.It is used mainly for the treatment of breast, ovarian, and non-small cell lung cancer.

3.Ithas an FDA approved claim for treatment of patients who have locally advanced, or metastatic breast or non small-cell lung cancer who have undergone anthracycline
based chemotherapy and failed to stop cancer progression or relapsed. An European 

approval  docetaxel for use in hormone-refractory prostate cancer. 

4.It is considered better than doxorubicin, paclitaxel and fluorouracil as a cytotoxic antimicrotubule. 

Docetaxel intermediate  is a crucial intermediate for Docitaxel, two of the best anti-cancer drugs ever invented. By extracting the precursor, docetaxel intermediate  in large quantites from the Taxus baccata leaf, many subsequent semisyntheses can be carried out. 
The esterification of docetaxel intermediate also causes an enhancement in the kinetics, and therefore the pharmacological profile of these important chemo-therapeutic agents.

Analysis	Standard
Assay(W/W)	98.0-102.0%
Purity(HPLC)	≥99.5%
Physical Control
Appearance	White crystalline powder
Identification	Conforms
Specific Optical Rotation	-40°~-47°
Water	≤3.0%
Chemical Control
Residue of solvents	Complies with ICH requirement
Residue on Ignition	NMT0.2%
Bacteria Endotoxins	0.4EU/MG
Heavy Metal	NMT20ppm
Chromatographic Impurities
Highest Individual Impurity	NMT0.1%
Unknown Impurity	NMT0.1%
Total Impurity	NMT0.5%
Microbiological Control
Total Aerobic Microbial Count	NMT 100cfu/g
S.Aureus & Aeruginosa	Negative
Salmonella & E.Coil	Negative
Storage
Store at 2-8°C, In well closed containers and protect from light and moisture.